What’s Happening in Your Body When You Eat Thanksgiving Dinner

Thanksgiving is practically synonymous with loved ones and giving thanks. But let’s be real: It also means plates piled high with food, a menagerie of desserts, flowing wine, and potential family drama.

For some, it’s the best time of the year (who doesn’t love a day of gluttonous eating with all of the people you love?). For others, the beginning of the holiday season marks the beginning of a time of pure stress — for your body and mind.

 

 

Read at Yahoo Finance

3D printing helps surgeons plan life-saving operation

A 3D-printed model of the blood vessels inside a woman’s brain has helped surgeons practise life-saving surgery.

The surgeons needed to operate to correct a weakness, or aneurysm, in a blood vessel inside the patient’s head.

Scans of the aneurysm revealed that the usual approach surgeons would take to fix it would not have worked.

3D printing is increasingly finding a role in medicine to either help doctors prepare before carrying out procedures or to make prosthetics.

After suffering vision problems and recurrent headaches, New York state resident Theresa Flint was diagnosed with an aneurysm that, if left untreated, would have proved fatal.

An aneurysm is a bulging blood vessel caused by a weakness in an artery wall that risks rupturing.

The usual way to treat such problems is to implant a metallic basket that strengthens the artery wall, said Dr Adnan Siddiqui, chief medical officer at the Jacobs Institute in Buffalo, New York, who directed the treatment.

 

Link to full article

 

Oil exploration techniques could aid cancer research

A Scottish university has been awarded a prestigious prize for research linking oil exploration engineering with studies into the formation of tumours.

Scientists at Heriot-Watt University have been investigating how oil flows through the tiny pore spaces in otherwise solid rock.

They claimed the principle can be applied to the movement of blood.

They said this could be important in the treatment of cancer.

The work has won a Queen’s Anniversary Prize from the Royal Anniversary Trust which recognises innovative work across different disciplines.

 

 

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Gene that makes bacteria immune to last-resort antibiotic can spread

A newly identified gene that renders bacteria resistant to polymyxin antibiotics—drugs often used as the last line of defense against infections—has the potential to be shared between different types of bacteria. The finding raises concern that the transferable gene could make its way into infectious bacteria that are already highly resistant to drugs, thereby creating strains of bacteria immune to every drug in doctors’ arsenal.

The gene, dubbed mcr-1, exists on a tiny, circular piece of DNA called a plasmid. These genetic elements, common among bacteria, are mobile; bacteria can make copies of them and share them with whatever bacteria happens to be nearby. Though scientists have previously discovered genes for polymyxin resistance, those genes were embedded in bacterial genomes, thus were not likely to easily spread.

 

Link to article on ArsTechnica

Birth of the Skin Microbiome

The immune system tolerates the colonization of commensal bacteria on the skin with the aid of regulatory T cells during the first few weeks of life, a mouse study shows.

 

he skin is home to millions of commensal bacteria and immune cells. Yet how the skin microbiome is established—in particular, why the immune system does not attack these bacteria—has been little studied. Now, a team led by researchers at the University of California, San Francisco (UCSF), has shown that, to establish tolerance by the immune system, colonization of the skin by commensal bacteria occurs during the first few days after birth in mice. The team’s findings were published today (November 17) in Immunity.

“This is an elegant and well-executed study showing a regulatory T cell–mediated establishment of commensal-specific tolerance,” said Keisuke “Chris” Nagao of the National Cancer Institute in Bethesda, Maryland, who was not involved in the work.

 

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Scientists find key to malaria growth

The key to malaria’s rampant growth has been explained by scientists.

They say it is down to protein molecules called cyclins which cause cells to divide rapidly in the malaria parasite.

The study, led by a team from the University of Nottingham, could lead to new treatments for malaria, the researchers said.

Malaria is responsible for nearly half a million deaths a year.

A cyclin is one of the most important protein molecules needed for cell division.

They have been well studied in humans, yeasts and plants – but until now, little has been known about cyclins in the malaria parasite and how they affect cell development.

This research, published in the journal PLoS Pathogens, has been able to classify the number and type of cyclins present in malaria parasites.

 

Read at BBC

Biological Compass

A protein complex discovered in Drosophila may be capable of sensing magnetism and serves as a clue to how some animal species navigate using the Earth’s magnetic field.

 

A variety of different animal species possess remarkable navigational abilities, using the Earth’s magnetic field to migrate thousands of miles every year or find their way home with minimal or no visual cues. But the biological mechanisms that underlie this magnetic sense have long been shrouded in mystery. Researchers in China may have found a tantalizing clue to the navigational phenomenon buried deep in the fruit fly genome. The team, led by biophysicist Can Xie of Peking University, discovered a polymer-like protein, dubbed MagR, and determined that it forms a complex with a photosensitive protein called Cry. The MagR/Cry protein complex, the researchers found, has a permanent magnetic moment, which means that it spontaneously aligns in the direction of external magnetic fields. The results were published today (November 16) in Nature Materials.

“This is the only known protein complex that has a permanent magnetic moment,” said Peter Hore, a physical chemist at the University of Oxford, U.K., who was not involved in the research. “It’s a remarkable discovery.”

 

Link to full article on The Scientist

Single course of antibiotics can mess up the gut microbiome for a year

In a battle against an infection, antibiotics can bring victory over enemy germs. Yet that war-winning aid can come with significant collateral damage; microbial allies and innocents are killed off, too. Such casualties may be unavoidable in some cases, but a lot of people take antibiotics when they’re not necessary or appropriate. And the toll of antibiotics on a healthy microbiome can, in some places, be serious, a new study suggests.

In two randomized, placebo-controlled trials of healthy people, a single course of oral antibiotics altered the composition and diversity of the gut microbiome for months, and in some cases up to a year. Such shifts could clear the way for pathogens, including the deadly Clostridium difficile. Those community changes can also alter microbiome activities, including interacting with the immune system and helping with digestion. Overall, the data, published Tuesday in the journal mBio, suggests that antibiotics may have more side effects than previously thought—at least in the gut.

 

Link to full article at Ars Technica

Cambridge Biomedical is seeking a Project Management Specialist

Project Management Specialist – Life Sciences/Biotech

Can you make order out of potential chaos?  Are details and follow-up your thing?

If so, keep reading.

Cambridge Biomedical professionals are experts in providing bio analytical services from preclinical through phase IV clinical trials. We have a proven track record of success in complex, custom biomarker and assay development, optimization, validation, and sample testing. We provide a diverse range of simple to highly complex, routine to esoteric assays; and we can accommodate study sizes with low, medium, or high volume sample testing requirements. Since 1997, Cambridge Biomedical has validated and placed into commercial diagnostic use over 150 assays across a wide variety of therapeutic areas for clients across the globe.

As a Project Management Specialist, you will handle a variety of complex, sensitive and confidential information while managing client issues and expectations.  You will be part of a scientific team that will rely upon you for creating project plans, tracking and following action items, identifying issues, and developing strategies for assuring timelines, budgets and quality metrics. 

Must Haves:

BS in Science, Chemistry, Molecular Biology or Biological Sciences

1-3 years’ experience in pharmaceuticals or equivalent

Fluent with Microsoft Office applications

Nice-to-haves:

Formal training in Project Management/expertise with PM software – a plus

Familiarity with GLP/GCLP/CAP/CLIA regulations – a plus

If you have what it takes, click here to send a resume to us and we’ll take it from there!