Lipids Take the Lead in Metastasis

Although metastasis is the leading cause of death among people with cancer, for the most part, researchers are stumped about which molecular signals allow malignant cells to leave primary tumors and start new ones. Two studies published in Nature this month highlight roles in metastasis for an unexpected group of molecules—lipids.

Read at The Scientist

Universal flu shots may be impossible thanks to duped immune cells

Flu viruses trick immune cells into fighting seasonal battles instead of all out war.

 

Ditching annual flu shots for a single stick that can protect year after year may be even harder to do than scientists thought—thanks to our own bamboozled immune systems.

Influenza viruses are infamous masters of mutation, changing themselves ever so slightly to dodge detection by immune cells. That viral variation drives the need for us to roll up our sleeves each fall instead of relying on our immune system’s memory of last year’s flu—or so researchers thought. A new study finds that although our immune systems naturally have the potential to detect and fight all flavors of flu virus, they get tricked into fighting only strain-specific battles. The finding, published Wednesday in Science Translational Medicine, suggests that making a universal vaccine may require wising up our immune cells as well as outsmarting the virus.

The study, from a group of researchers led by Patrick Wilson of the University of Chicago, examined the immune responses of 21 people after exposures to the 2009 H1N1 virus (swine flu). Researchers specifically looked at participants’ B cells, which make antibodies that help fend off the flu by seeking out the virus and marking it for an attack, as well as seeking out the antibodies themselves.

 

Link to full article

Cambridge Biomedical Releases Latest Whitepaper-Immunological Techniques

Cambridge Biomedical  released the latest in it’s series of whitepapers titled “Application of Immunological Methods to the Biology, Diagnosis and Treatment of Diseases” by Dr. Sonal Gupta.

 

Overview: Immunology is defined as the branch of Biomedical Sciences concerned with all aspects of the
immunological framework in all multicellular organisms. Modern immunological techniques at
Cambridge Biomedical have a wide range of applicability, from Basic Science, Translational research to
Clinical Application. Described here are some of the disease areas in which we have applied our
considerable expertise in immunology.

 

Read full paper here