Approaching Zero: How West Africa is Crushing the Ebola Epidemic

The West African Ebola outbreak is finally starting to approach manageable levels, after nearly 18 excruciating months and over 11,000 lost lives. Here’s what the current situation on the ground looks like and how the battle against Ebola finally might be won.

This is the largest and longest Ebola outbreak in human history. At its peak, there were 950 confirmed cases each week, prompting fears of a global pandemic. Officials have reported 28,421 confirmed, probable, and suspected cases in Guinea, Liberia, and Sierra Leone. Of these, some 11,300 people have died — a fatality rate of 40%. A total of 881 healthcare workers have been infected; of those, 513 died.

The effects will be felt for years to come. The loss of so many medical personnel is expected to have downstream effects on the health system of affected West African countries, including a sharp rise in maternal mortality to the tune of an additional 4,022 deaths each year for the foreseeable future. Moreover, the ability of healthcare workers to deal with other major diseases, like Malaria and Lassa (another hemorrhagic fever), was severely curtailed during the epidemic.

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3D simulation depicting how a tumor grows

Healthy tissues are like healthy ecosystems: Both composed of diverse populations. But in tumors, a single, malignant cell type often dominates. A new computer model is helping researchers understand why, and it could pave the way to more effective cancer treatments.

Using mathematical algorithms, a team of researchers has developed a new, 3D simulation depicting how a tumor grows from a handful of rogue cell types (represented by different colors) into a malignant mass comprised of millions of cancerous mutants. The model, published this week in Nature, is reinforcing something that laboratory studies have also shown: Tiny movements of cells within a tumor can cause the mass to quickly expand, or allow it to rebound after chemotherapy.

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